Find out how to get Vyleesi
Learn MoreReconnect with your desire
Vyleesi is the first and only FDA-approved as-needed treatment for hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have low sexual desire that is troubling to them.
Developed to help women rekindle their sexual desire—on their terms.
“Acquired” means that you were happy with your level of sexual desire in the past, but it has recently decreased. “Generalized” means that your level of sexual desire is the same, no matter the sexual activity, situation, or sexual partner.
Take Vyleesi as needed at least 45 minutes before anticipated sexual activity.
Do not take Vyleesi more than one time within 24 hours or more than 8 times per month.
The benefits
of Vyleesi
Sexual desire is connected to our self-esteem and the intimacy we have with our partners. If you’re frustrated by low sexual desire, Vyleesi may be for you. Here’s why:
Increases sexual desire
And reduces related distress.
Taken when you choose
You say when the time is right.
For romance, fun, or just because.
Starts working in ~45 minutes
And lasts up to 16 hours, although your experience may be different.*
No alcohol restrictions
Say cheers to your connection.
Vyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.†
*Do not take Vyleesi more than one time within 24 hours or more than 8 times per month.
†Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.
Find out how Vyleesi works
Learn MoreVyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.†
*Do not take Vyleesi more than one time within 24 hours or more than 8 times per month.
†Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.
Open the door
to desire
Talk to your doctor, or go through our trusted third party telemedicine partner to get Vyleesi prescribed and delivered from the comfort of your home.
Most eligible patients pay $0 for their prescription!‡
Answer a few questions
Fill out a quick and private medical questionnaire to see if what you’re experiencing is HSDD.
Connect online
Our trusted third party telemedicine partner, experienced in HSDD, will see if Vyleesi is right for you.
Get Vyleesi at your door
If you get a prescription, Vyleesi will ship directly and discreetly, for free.
Need help talking about it?
Learn MoreLow Desire? Could I have HSDD?
Millions of women experience low desire associated with HSDD, but many haven’t even heard of it. While it’s normal to experience changes in your level of desire, an ongoing struggle to get in the mood can point to an imbalance of chemicals in your brain. The good news is it can be treated. And when it is, women can get back to butterflies, goosebumps, and all the things that come with desire.
Take our short quiz below to find out if what you’re experiencing could be HSDD.
Vyleesi:
the desired results
In a study with real women who struggled with the frustration of low sexual desire, Vyleesi was clinically proven to increase sexual desire and reduce related stress, which impacts overall wellness. In fact, nearly 80% of women who completed the study volunteered for an additional one-year extension. Here are some of their stories.
Vyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.†
†Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.
Real clinical trial participants
Vyleesi is affordable
Here’s how to get your Vyleesi prescription:
- Vyleesi is only available through a specialty pharmacy called KnippeRx.
- Vyleesi is affordable; most commercially insured patients pay $0 for Vyleesi.‡
- KnippeRx, helps all patients get Vyleesi for the lowest price with FREE SHIPPING!
- If you already have a prescription for Vyleesi, you can contact KnippeRx directly at 833-912-0764 or visit www.knipperx.com. They can answer any questions you may have.
What is HSDD?
1 in 10 women experience low libido associated with HSDD (Hypoactive Sexual Desire Disorder).
It’s the most common medical condition to cause sex-related distress for women—affecting self-esteem and putting a strain on relationships—but many women don’t discuss it with their doctors, and it often goes undiagnosed. If you’re experiencing an ongoing and frustrating lack of sexual desire, you’re not alone. Understand what causes HSDD and see if FDA-approved Vyleesi is the right treatment option for you.
Are you experiencing HSDD?
Symptom CheckerTo change the conversation, we have to start it.
Stay connected for important information and resources on
Low Libido associated with HSDD
Frequently asked questions
That’s the abbreviation for hypoactive sexual desire disorder. It’s a common, treatable medical condition characterized by ongoing low sexual desire that women find frustrating (“hypoactive” means “low”).
If you’re diagnosed with “acquired, generalized” HSDD, it means you haven’t had low sexual desire in the past, but you now have low sexual desire no matter the sexual activity, situation, or sexual partner.
If you’ve never heard of HSDD, you’re not alone. One survey showed that 72% of premenopausal women weren’t aware of HSDD,* even though about 10% of premenopausal women in the US have it.
Think you have symptoms of HSDD? Check it out.
*Kingsberg S.A. Attitudinal survey of women living with low sexual desire. J Women’s Health. 2014;23(10):8
Vyleesi (bremelanotide injection) is the first and only FDA-approved as-needed treatment for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). It was approved by the FDA on June 21, 2019.
Do not use if you have:
- high blood pressure that is not controlled (uncontrolled hypertension)
- known heart (cardiovascular) disease
Here’s what two identically designed clinical trials with over 1,200 premenopausal women with HSDD* showed:
Vyleesi increased sexual desire and reduced related distress.
Women who took Vyleesi experienced continued meaningful improvement of HSDD symptoms, with nearly 80% of women who completed the clinical study volunteering for an additional one-year extension.
The most common side effects are nausea, flushing, injection site reactions, headache, and vomiting.†
*The effectiveness and safety of Vyleesi were studied in two identical trials in over 1,200 premenopausal women with acquired, generalized HSDD for at least six months. Ages ranged from 19-56 years old, with an average age of 39 years old; 86% were White and 12% were Black. The trials had two phases: a 24-week Core Study Phase (24-week placebo-controlled, double-blind treatment period) and an uncontrolled 52-week Open-label Extension Study Phase in which nearly 700 patients received Vyleesi. Most people who received Vyleesi used it two to three times per month and no more than once a week.
†Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.
