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With Vyleesi, desire is on your terms

The only FDA-approved peptide for low libido
Vyleesi is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in certain women who have not gone through menopause.

With Vyleesi, desire is on your terms

The only FDA-approved peptide for low libido
Vyleesi is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in certain women who have not gone through menopause.

How vyleesi works

Vyleesi reignites desire in your brain

Scientific studies show that sexual desire begins in the brain, where chemical messengers activate specific pathways. Vyleesi is a nonhormonal treatment designed to work with those pathways. It mimics natural signals and activates melanocortin receptors—essential switches that help turn on sexual desire. In short: Vyleesi helps flip the brain’s “on switch” for desire.

Vyleesi fits seamlessly into your life:

FDA approved—proven to increase your desire and reduce your distress
Take Vyleesi 45 minutes prior to sexual activity. Vyleesi reaches maximum concentration in your body within 30–60 minutes
You choose when to spark your desire—no daily dosing! 
Safe to use with alcohol—date night approved!

“I’ve been having more sexual thoughts and more interest in initiating.”

– Real clinical trial participant

Vyleesi results: the stats behind the spark*

In clinical trials, women taking Vyleesi saw:

Significant boost in desire:
164% INCREASE in desire (+0.58 mean change) vs those taking placebo (+0.22 mean change)†
Notable decrease in distress:
75% DECREASE in distress related to sexual desire (-0.7 mean change) vs those taking placebo (-0.4 mean change)‡
*The Vyleesi pivotal trials measured improvements in HSDD symptoms. The efficacy and safety of Vyleesi was studied in 2 identical, 24-week, randomized, double-blind, placebo-controlled trials in 1247 premenopausal women with acquired, generalized HSDD.
†Scores range from 1.2 (lowest desire) to 6 (highest desire).
‡Scores range from 0 (Never feel bothered) to 4 (Always feel bothered).

“I hadn’t felt the desire in so long. But it was a joy for me for the same reason; I hadn’t felt it in so long.”

– Real clinical trial participant

HOW TO USE VYLEESI

Reignite your desire with the click of a pen

Anytime, anywhere—you choose the moment to reignite your passion. With the compact autoinjector, just one easy “click” in the abdomen or thigh brings Vyleesi (and you!) into action.

Compact and fridge-free, it goes wherever life (and desire) takes you

Made for one-time use, the medicine is fully injected in ~5 seconds
Has a thin, nonvisible needle with a protective guard
Not actual size.

How to use the Vyleesi autoinjector

Using the Vyleesi autoinjector only takes a few seconds! For in-depth instructions, follow the link below and get your “click” on.
Pull the clear cap from the autoinjector to activate
Place the purple tip flat against the abdomen or thigh
Press down and hold the autoinjector against your skin. You’ll hear it click when it starts to administer Vyleesi. When you hear a second click, wait 5 seconds before removing
Check to make sure the view window is purple with a little gray tip still showing and lift the pen straight out
Download full Instructions for Use

Understanding possible side effects

Some women may experience side effects, the most common being nausea, flushing, injection site reactions, headaches, and vomiting.

A note about nausea before your first dose

You may experience some nausea after your first dose; it may start during the first hour and last for about 2 hours.

Nausea improved for most women with the second dose, but could occur intermittently with continued use.

Some patients prefer to start with their first dose on a day when they don’t have big plans, so they can see how their body responds.

Nausea events were mostly mild to moderate and typically didn’t require treatment. If nausea bothers you, ask your healthcare provider about prescribing an antiemetic (anti-nausea and vomiting) treatment.

Reports of nausea

21% first dose
3% second dose
2% third dose

Desire, delivered in 3 easy steps

How to get Vyleesi

Vyleesi gets prescribed and submitted, fast!

Your healthcare provider sends your Vyleesi prescription to BlinkRx, a digital pharmacy platform. With BlinkRx, you can be sure you are getting the lowest price using all available discounts.
Get Vyleesi ONLINE through third-party telemed partner

BlinkRx sends you a text

BlinkRx will send you a link on the same day. You’ll pay online or by phone and get home delivery for free! They’ll let you know about the copay, help with any approvals, and apply savings offers. Most commercially insured patients pay $0 for a 4-dose box of Vyleesi.§ If you don’t have insurance coverage for Vyleesi, a 4-dose box is available for just $99.

Vyleesi, right to your door

Desire gets delivered—discreetly! BlinkRx will arrange for your Vyleesi  to be sent straight to your home. Have questions about delivery? 
Just give BlinkRx a call at 1 (833) 799-5028 or visit blinkrx.com.
You could
Pay $0 for Vyleesi
For questions, call BlinkRx at 1 (833) 799-5028 or visit blinkrx.com
Commercial insurance not covered? Fill a 4-dose prescription for just $99.
§Depending on insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc) are not eligible. Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Cosette contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Cosette copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.

the lowdown on low libido

Sexual desire starts in the brain

Hypoactive sexual desire disorder (HSDD) is a medical condition that is associated with ongoing and frustrating lack of interest in sex (low libido).

Desire isn’t just about the body; it’s about the brain.

From quiet daydreams to sudden thrills, the brain—especially among women—drives sexual desire. In women diagnosed with HSDD, an imbalance of neurotransmitters (chemical messengers) in the brain may result in low sexual desire.

HSDD also causes distress related to low desire.

This may manifest as feelings of frustration, sadness, or relationship strain. But if you’re experiencing HSDD, it’s not the fault of you or your relationship, and you’re not alone. Plenty of women struggle with HSDD.
HSDD affects ~1 in 10 women in the US

Could you be experiencing HSDD?

The Decreased Sexual Desire Screener (DSDS) is a simple tool to help you start the conversation about HSDD with your healthcare provider.
You can review it together and talk through what you’re experiencing, and your healthcare provider can help explain the results and work with you to decide next steps.
Download the Screener

Dive Into Desire Videos

Understanding HSDD

Hear from Dr. Jenni as she discusses HSDD and how an FDA-approved treatment option may help increase desire and reduce distress in premenopausal women.

Important Safety Information

Do not use Vyleesi if you have:
  • high blood pressure that is not controlled (uncontrolled hypertension) or known heart (cardiovascular) disease

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Important Safety Information

Do not use Vyleesi if you have:
  • high blood pressure that is not controlled (uncontrolled hypertension) or known heart (cardiovascular) disease
Before using Vyleesi, tell your healthcare provider about all of your medical conditions, including if you:
  • have high blood pressure,
  • have heart problems,
  • have kidney problems,
  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if Vyleesi will harm your unborn baby.
  • Women who can become pregnant should use effective birth control during treatment with Vyleesi.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Vyleesi may affect the way other medicines work, and other medicines may affect the way Vyleesi works.

How should I use Vyleesi?
  • Inject Vyleesi at least 45 minutes before you think that you will begin sexual activity.
  • Do notinject more than 1 dose of Vyleesi within 24 hours of your last dose.
  • Do notinject more than 8 doses of Vyleesi within a month.
What are the possible side effects of Vyleesi? Vyleesi can cause serious side effects, including:
    • Temporary increase in blood pressure and decrease in heart rate: An increase in blood pressure and decrease in heart rate can happen shortly after you inject Vyleesi. These changes usually go away within 12 hours after your injection. Increases in blood pressure and an increased risk of heart (cardiovascular) problems can happen if you use Vyleesi more often than prescribed by your healthcare provider.
    • Darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast. The chance of darkening of the skin is increased in people with darker skin color. The chance of darkening of the skin is higher if Vyleesi is used every day. Darkening of the skin may not go away, even after you stop using Vyleesi.
  • Nausea. Nausea is common and can also be severe. Nausea most commonly happens after the first Vyleesi injection but can also happen after any dose of Vyleesi. The nausea usually lasts for about 2 hours but can last longer in some people. The nausea usually goes away by itself. Tell your healthcare provider if you have nausea that is severe or does not go away.

The most common side effects of Vyleesi include: flushing, injection site reactions, headache, vomiting, cough, fatigue, hot flush, tingling, dizziness, and nasal congestion. These are not all the possible side effects of Vyleesi.

Call your doctor for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or fda.gov/medwatch.

Indication

What is Vyleesi?

Vyleesi is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have low sexual desire that is troubling to them. Their low sexual desire is not due to:

  • a medical or mental health problem
  • problems in the relationship
  • medicine or other drug use

Vyleesi is not for the treatment of HSDD in women who have gone through menopause or in men.

Vyleesi is not for use to improve sexual performance.

Vyleesi is not for use in children.

Pay $0 for Vyleesi

Commercially approved patients pay $0 for a 4-dose box of Vyleesi. If coverage is denied, a 4-dose box is available for $99.

Connect with a licensed physician to see if Vyleesi is right for you.

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Terms & Conditions

*Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Cosette contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Cosette copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.

Get a diagnosis

If your healthcare provider suspects that you may have HSDD, he or she will likely ask you 5 questions from the Decreased Sexual Desire Screener (DSDS). Here’s what to expect:

  1. In the past, was your level of sexual desire or interest good and satisfying to you?
  2. Has there been a decrease in your level of sexual desire or interest?
  3. Are you bothered by your decreased level of sexual desire or interest?
  4. Would you like your level of sexual desire or interest to increase?
  5. Please check any of the factors that you feel may be contributing to your current decrease in sexual desire or interest:

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Getting back your desire with Vyleesi could be just a few clicks away.

Most eligible patients will pay $0 for their Vyleesi prescription!*

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Cosette is not affiliated with healthcare providers, does not make any recommendations of specific healthcare providers, and is not responsible for information you share with them. Any prescription is the decision of the healthcare provider alone, based on the patient’s needs. Cosette does not accept any responsibility for the care, treatment, or advice received from any healthcare provider.

*View complete eligibility terms & conditions

Terms & Conditions

‡Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Cosette contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Cosette copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.