What is HSDD?

Hypoactive—“hypo” meaning low—Sexual Desire Disorder is an ongoing and frustrating lack of interest in sex, not to be confused with ability. Women with HSDD still have sex; it’s just not the same.

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HSDD is common.

In fact, approximately 1 in 10 women in the US experience it.

Affecting millions of women—mothers, girlfriends, and even teenagers—but most women haven’t heard of HSDD.

What causes HSDD?

From vivid fantasies to thudding heartbeats, the brain—especially amongst women—is responsible for sexual desire. Meaning if you experience HSDD, you and your relationship are not to blame. What it could be is an imbalance in neurotransmitter (chemical messengers) activity in the brain that causes low sexual desire.

Check your symptoms
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Vyleesi is for women with low libido associated with HSDD

Vyleesi is for women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner.

Do not use Vyleesi if you have:
• high blood pressure that is not controlled (uncontrolled hypertension)
• known heart (cardiovascular) disease

About Vyleesi

Here’s how HSDD may be affecting your overall sexual wellness

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Negative body image

No one can make you feel as sexy as you can make yourself feel. HSDD can impact the way you see yourself, making you less excited to put on that favorite bra and appreciate the beauty that’s right in front of you.

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Avoiding intimacy

Sexual desire strengthens the physical and emotional connection of relationships. Disinterest in the romance you used to crave can leave you feeling disconnected from your partner.

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Low self-esteem

For many women who experience HSDD, feeling like there is something wrong with you or like something’s missing can really impact your confidence.

How do you know if you have HSDD?

Because HSDD is a medical condition, you would need to consult your healthcare professional, either in person or through telemedicine. There is no single lab test to confirm the diagnosis of HSDD.

A validated tool for diagnosing HSDD is the
Decreased Sexual Desire Screener (DSDS),
a short series of questions that focus on the symptoms of HSDD.

HSDD Symptom Checker

If you’re not sure if you’re ready to talk to a doctor about your low sexual desire, checking if your symptoms point to HSDD can help you decide.

Let's find out
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Frequently Asked Questions

What’s Vyleesi?

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What are the possible side effects of Vyleesi?

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Does Vyleesi work?

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Important Safety Information

Do not use Vyleesi if you have:
    high blood pressure that is not controlled (uncontrolled hypertension)
    known heart (cardiovascular) disease

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Important Safety Information

Do not use Vyleesi if you have:
    high blood pressure that is not controlled (uncontrolled hypertension)
    known heart (cardiovascular) disease
Before using Vyleesi, tell your healthcare provider about all of your medical conditions, including if you:
    have high blood pressure.
    have heart problems.
    have kidney problems.
    have liver problems.
    are pregnant or plan to become pregnant. It is not known if Vyleesi will harm your unborn baby.
      Women who can become pregnant should use effective birth control during treatment with Vyleesi.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Vyleesi may affect the way other medicines work, and other medicines may affect the way Vyleesi works.

How should I use Vyleesi?
    Inject Vyleesi at least 45 minutes before you think that you will begin sexual activity.
    Do not inject more than 1 dose of Vyleesi within 24 hours of your last dose.
    Do not inject more than 8 doses of Vyleesi within a month.
What are the possible side effects of Vyleesi? Vyleesi can cause serious side effects, including:

    Temporary increase in blood pressure and decrease in heart rate: An increase in blood pressure and decrease in heart rate can happen shortly after you inject Vyleesi. These changes usually go away within 12 hours after your injection. Increases in blood pressure and an increased risk of heart (cardiovascular) problems can happen if you use Vyleesi more often than prescribed by your healthcare provider.
    Darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast. The chance of darkening of the skin is increased in people with darker skin color. The chance of darkening of the skin is higher if Vyleesi is used every day. Darkening of the skin may not go away, even after you stop using Vyleesi.
    Nausea. Nausea is common and can also be severe. Nausea most commonly happens after the first Vyleesi injection but can also happen after any dose of Vyleesi. The nausea usually lasts for about 2 hours but can last longer in some people. The nausea usually goes away by itself. Tell your healthcare provider if you have nausea that is severe or does not go away.

The most common side effects of Vyleesi include: flushing, injection site reactions, headache, vomiting, cough, fatigue, hot flush, tingling, dizziness, and nasal congestion. These are not all the possible side effects of Vyleesi.

Call your doctor for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or fda.gov/medwatch.

INDICATION What is Vyleesi?

Vyleesi is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have low sexual desire that is troubling to them. Their low sexual desire is not due to:

    a medical or mental health problem
    problems in the relationship
    medicine or other drug use

Vyleesi is not for the treatment of HSDD in women who have gone through menopause or in men.

Vyleesi is not for use to improve sexual performance.

Vyleesi is not for use in children.

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Terms & Conditions

*Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Cosette contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Cosette copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.

Get a diagnosis

If your healthcare provider suspects that you may have HSDD, he or she will likely ask you 5 questions from the Decreased Sexual Desire Screener (DSDS). Here’s what to expect:

  1. In the past, was your level of sexual desire or interest good and satisfying to you?
  2. Has there been a decrease in your level of sexual desire or interest?
  3. Are you bothered by your decreased level of sexual desire or interest?
  4. Would you like your level of sexual desire or interest to increase?
  5. Please check any of the factors that you feel may be contributing to your current decrease in sexual desire or interest:

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Cosette is not affiliated with healthcare providers, does not make any recommendations of specific healthcare providers, and is not responsible for information you share with them. Any prescription is the decision of the healthcare provider alone, based on the patient’s needs. Cosette does not accept any responsibility for the care, treatment, or advice received from any healthcare provider.

*View complete eligibility terms & conditions

Terms & Conditions

‡Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Cosette contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Cosette copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.